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M94A2588.TXT
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Document 2588
DOCN M94A2588
TI Prevalence of gynecologic infections in a cohort of HIV-infected women.
DT 9412
AU Spence M; Gagmon S; Cohn J; Harrison D; Brinson C; Stein A; Hellinger J
SO Int Conf AIDS. 1994 Aug 7-12;10(1):27 (abstract no. 083B). Unique
Identifier : AIDSLINE ICA10/94369987
AB OBJECTIVE: To describe the prevalence of vaginal candidiasis (vc) and
sexually transmitted diseases (STDs) in a broad based cohort of
immunosuppressed HIV- infected women. METHODS: HIV-infected women in 6
U.S. cities with a CD4 count < or = 500 and no recent history of
cervical dysplasia were enrolled by their primary care physicians and
questioned on their past and current sexual practices. History of
gynecological infections was obtained and a complete pelvic examination
was performed. RESULTS: Preliminary data are available on 86 of 126
women enrolled. Median age of the population was 33 years (R, 20-52).
Median number of sexual partners during the 6 months prior to study
entry was only 1 (R, 0-4) compared to a median number of lifetime sexual
partners of 10 (R, 1-1000). Eighty-three % had a history of vc.
Twenty-one % had vc on pelvic examination including 30% of 20 patients
receiving daily suppressive antifungal therapy during the past four
weeks. Thirty-seven % had a history of trichomonas, 26% genital herpes
(HSV), 26% gonorrhea (GC), 20% chlamydia, 19% pelvic inflammatory
disease (PID) and 9% syphilis. Four % had trichomonas at the time of
exam and 3% had HSV, but none had GC, chlamydia, PID or syphilis.
CONCLUSION: The majority of immunosuppressed HIV-infected women have had
vaginal candidiasis and at least one STD in addition to HIV. VC was the
most prevalent gynecologic infection and was seen in 30% of patients
receiving chronic suppressive antifungal therapy. Safer sex practices
including fewer partners may explain the low prevalence of STDs in these
patients.
DE Adult Antifungal Agents/THERAPEUTIC USE AIDS-Related Opportunistic
Infections/*COMPLICATIONS Candidiasis, Vulvovaginal/COMPLICATIONS/DRUG
THERAPY Female Human HIV Infections/*COMPLICATIONS Middle Age Sex
Behavior Sexually Transmitted Diseases/*COMPLICATIONS MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).